David Craig, a biotechnology founder and industry operator, has announced the release of his book "The New Rules of Biotech: A Founder's Guide to Building Great Companies" in hardcover ($29.99) and audiobook on Google Play. The book, previously available in paperback and Kindle editions through Amazon, offers a practical playbook for founders, investors, and operators navigating the changed biotech landscape.
The book addresses the reality that the biotech strategies that worked in 2021 are no longer viable. Capital has become more expensive, the FDA's standards have shifted, and the Inflation Reduction Act has fundamentally altered drug economics before approval. Investors now demand capital efficiency and clear paths to value, rather than funding speculative slide decks. Craig draws on his experience founding and running a preclinical biotech to provide an operating manual for building companies under these conditions.
The guide covers critical decisions such as choosing between a platform and an asset, selecting an affordable modality, raising seed rounds against milestones, and using non-dilutive capital strategically. It walks readers through IND-enabling work, CMC, clinical decisions, term sheets, board dynamics, business development, and exit strategies. Each chapter includes separate takeaways for operators and investors, making the book useful for both sides of the table.
Craig's motivation for writing the book stems partly from a personal connection to a rare genetic muscle disease, RYR-1 related congenital muscular dystrophy, which underscores his argument that biotech company building carries a responsibility beyond financial returns. He stated, "Founders and operators take in ideas in different ways. The hardcover is there for the people who want a durable copy on the desk, the paperback and Kindle for everyone else, and the audiobook on Google Play for those who prefer to listen on the move."
The book is available in multiple formats: hardcover at Amazon, paperback at Amazon, Kindle at Amazon, and audiobook on Google Play. Published by D. Craig Consulting LLC, the book falls under the categories of Business and Money, Business Development and Entrepreneurship, and was originally published on June 8, 2026.
David Craig is the founder and CEO of Sarcomatrix Therapeutics Corp. and principal of D. Craig Consulting LLC. He has worked in the pharmaceutical and biotechnology industry since 1986.
